Notes

Note 12. What the evidence supports
What the twelve-week study supports, who it was measured in, where the evidence stops, and how to decide. Read more...
Note 11. The cycle and the timeline
One OF·27 cycle is four weeks of twice-daily application, two metered doses a day. Read more...
Note 10. The protocol
The OF·27 protocol is a fixed-dose topical regimen supplied in a 50 millilitre airless pump. Read more...
Note 09. The study
The OF·27 clinical assessment is a twelve-week, single-blind, vehicle-controlled trichoscopy study conducted by Abich, an independent testing laboratory, under reference REL/0504/2026, in forty participants. Read more...
Note 08. Measuring density: trichoscopy
Trichoscopy is the examination of the scalp and hair with a dermoscope, a magnifying instrument that images the surface under controlled lighting. Read more...
Note 07. FGF-7 and hair density
FGF-7, keratinocyte growth factor, is a signaling protein produced by the dermal papilla cells at the base of the hair follicle, where it acts on the keratinocytes that form the hair shaft. Read more...
Note 06. The platform
Core Biogenesis is a biotechnology company founded in 2020 in France that produces recombinant proteins using plants rather than the bioreactors conventionally used for the purpose. Read more...
Note 05. Oleosome-protein fusion
Oleosome-protein fusion is a method in which a recombinant protein is produced already attached to an oleosome, a natural lipid carrier found in plant seeds. Read more...
Note 04. Signaling versus irritation
Topical actives that affect the skin generally work in one of two ways. Read more...
Note 03. The delivery problem
The outermost layer of skin, the stratum corneum, is a barrier built to keep large molecules out. Read more...
Note 02. Growth-factor signaling in the follicle
Growth factors are signaling proteins that bind receptors on a cell surface and instruct the cell to divide, differentiate, or stay active. Read more...
Note 01. The biology of hair-density decline
Hair density is the number of hairs growing in a given area of scalp, usually counted per square centimetre. Read more...
Note 00. What this is
OF·27 is an independent topical hair-density program built on FGF-7 and FGF-2 actives, with the active supplied by Core Biogenesis. Read more...