The oleosome
An oleosome is an oil body: a droplet of plant oil wrapped in a single layer of phospholipids and studded with small structural proteins called oleosins. Seeds use them to store energy. Core Biogenesis uses them as a carrier. The growth factor is grown fused to an oleosin, so as the seed forms, the protein is already sitting on the surface of the oil body.
This is what solves the stability problem in Note 03. A free growth factor in a water-based formula is fragile. Anchored to an oleosome, the same protein is held in a stable, lipid-bound form, protected from the oxidation and clumping that defeat most topical proteins. It travels as part of the carrier rather than as a loose molecule, in the bottle and on the scalp.
Carrying proteins on plant oil bodies is documented in the literature (van Rooijen and Moloney, 1995, cited on the homepage). The specific fusion in OF·27 is the supplier's, and its performance data belong to them.
Both actives, FGF·2 and FGF·7, are made this way. The platform that grows them is the subject of Note 06.
What is oleosome-protein fusion?
A method in which a recombinant protein is expressed bound to the surface of an oleosome, a natural plant-seed lipid body, so it stays intact rather than degrading in a water-based formula.
How are the actives produced?
They are expressed in the seeds of Camelina sativa bound to oleosomes by Core Biogenesis, the maker of the actives.
The notes, by email.
One note at a time, in reading order, and a message when a new one is published.
An independent hair-science program.
The protocol the notes describe: The OF·27 Protocol
OF·27 is marketed as a cosmetic and is not intended to diagnose, treat, cure or prevent any disease.