An oleosome is an oil body: a droplet of plant oil enclosed in a single layer of phospholipids, studded with structural proteins called oleosins. Seeds use them to store energy. Core Biogenesis uses them as a carrier, by expressing a target protein fused to an oleosin so that the protein is displayed on the oil body's surface as the seed forms.
This is the mechanism the delivery problem in Note 03 requires. A free growth factor applied to skin is large, water-soluble, and quick to degrade, and it largely stops at the surface. Anchored to an oleosome, the same protein is held in a stable, lipid-bound form. The company has reported that the fusion stabilises protein structure by roughly eight to ten times relative to the unbound protein, and that in skin-explant studies oleosome-bound protein reached the dermis while the unbound protein stayed in the epidermis.
Two properties follow from the structure. The lipid envelope shields the folded protein from the oxidation and aggregation that defeat conventional topical growth factors, and the oil body's affinity for lipid helps carry its cargo through the stratum corneum toward the living tissue below. The protein travels as part of the carrier rather than as a free molecule exposed to the formulation around it.
The same expression-and-fusion process is applied to both proteins the program uses, FGF-7 and FGF-2, described in Note 02. The platform that produces them is the subject of Note 06.