FGF-7, keratinocyte growth factor, is a signaling protein produced by the dermal papilla cells at the base of the hair follicle, where it acts on the keratinocytes that form the hair shaft. It is one of the factors involved in regulating the follicle's growth phase, the phase that determines how much each follicle contributes to overall density.
Its position in the follicle is the reason OF·27 is built around it. The dermal papilla sits in the dermis, beneath the barrier documented in Note 03, and FGF-7 normally signals to the surrounding epithelial cells from there. A topical form of FGF-7 therefore has to reach the dermis to act in the location where the protein operates in the body. This is the requirement the oleosome fusion in Note 05 is built to meet.
OF·27 pairs FGF-7 with FGF-2. The two cover complementary roles documented in Note 02: FGF-7 acting on the shaft-forming keratinocytes, FGF-2 in proliferation and in the vascular supply to the follicle. Both are produced as oleosome fusions on the Core Biogenesis platform and formulated together.
What this pairing does in practice is a measurement question, not a claim. The program's assessment of it is the trichoscopy study documented in Note 08 and Note 09. This note documents why these two proteins, in this location, are the ones the program selected.